线上赌博app

Congratulations! The publication of our group in J. Am. Chem. Soc., "Catalytic Enantioselective Aminative Difunctionalization of Alkenes" has been published recently (Nan Huang, Jie Luo, Lihao Liao, and Xiaodan Zhao* J. Am. Chem. Soc., 2024, 146, 7029-7038).

  Enantioselective difunctionalization of alkenes offers a straightforward means for the rapid construction of enantioenriched complex molecules. Despite the tremendous efforts devoted to this field, enantioselective aminative difunctionalization remains a challenge, particularly through an electrophilic addition fashion. Herein, we report an unprecedented approach for the enantioselective aminative difunctionalization of alkenes via copper-catalyzed electrophilic addition with external azo compounds as nitrogen sources. A series of valuable cyclic hydrazine derivatives via either [3 + 2] cycloaddition or intramolecular cyclization have been achieved in high chemo-, regio-, enantio-, and diastereoselectivities. In this transformation, a wide range of functional groups, such as carboxylic acid, hydroxy, amide, sulfonamide, and aryl groups, could serve as nucleophiles. Importantly, a new cyano oxazoline chiral ligand was found to play a crucial role in the control of enantioselectivity.

Previous page: Enantioselective cross-dehydrogenative coupling enabled by organocatalysis

Next page: Catalytic 1,1-diazidation of alkenes