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 Organoselenium-Catalyzed Synthesis of Oxygen- and Nitrogen-Containing Heterocycles

From : Our Group            Refresh Time : Feb 13, 2016

      Congratulations! The first publication of our group in 2016, "Organoselenium-Catalyzed Synthesis of Oxygen- and Nitrogen-Containing Heterocycles" has been published in ACS Journal, Organic Letters (Ruizhi Guo, Jiachen Huang, Haiyan Huang, and Xiaodan Zhao* Org. Lett. 2016, 18, 504-507).

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      A new and efficient approach for the synthesis of oxygen and nitrogen heterocycles by organoselenium catalysis has been developed. The exo-cyclization proceeded smoothly under mild conditions with good functional group tolerance and excellent regioselectivity. Mechanistic studies revealed that 1-fluoropyridinium triflate is key for oxidative cyclization.

 

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