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 Enantioselective Trifluoromethylthiolating Lactonization Catalyzed by an Indane-Based Chiral Sulfide

From : Our Group            Refresh Time : May 4, 2016

      Congratulations! The first publication of our group in Angew. Chem. Int. Ed, "Enantioselective Trifluoromethylthiolating Lactonization Catalyzed by an Indane-Based Chiral Sulfide" has been published recently (Xiang Liu, Rui An, Xuelin Zhang, Jie Luo, and Xiaodan Zhao* Angew. Chem. Int. Ed. 2016, 55, 5846–5850).

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      An efficient approach for enantioselective trifluoromethylthiolating lactonization entails the use of an indane-based bifunctional chiral sulfide catalyst and a new shelf-stable electrophilic SCF3 reagent. This transformation represents the first enantioselective trifluoromethylthiolation that is enabled by a catalyst with a Lewis basic sulfur center.

      This research was rated as the inside back cover.

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