Organoselenium-Catalyzed, Hydroxy-Controlled Regio- and Stereoselective Amination of Terminal Alkenes: Efficient Synthesis of 3-Amino Allylic Alcohols
Congratulations! The first publication of our group, "Organoselenium-Catalyzed, Hydroxy-Controlled Regio- and Stereoselective Amination of Terminal Alkenes: Efficient Synthesis of 3-Amino Allylic Alcohols" has been published in ACS Journal, Organic Letters (Zhimin Deng, Jialiang Wei, Lihao Liao, Haiyan Huang, and Xiaodan Zhao*. Org. Lett. 2015, 17, 1834-1837).
An efficient route to prepare 3-amino allylic alcohols in excellent regio- and stereoselectivity in the presence of bases by orangoselenium catalysis has been developed. In the absence of bases α,β-unsaturated aldehydes were formed in up to 97% yield. Control experiments reveal that the hydroxy group is crucial for the direct amination.
Previous page: The 4th Lingnan Organic Chemistry Forum