Lewis Acid-Mediated Electrophilic Thiolative Difunctionalization of Enimides: Rapid Access to β-Amino Sulfides
Congratulations! The publication of our group in Org. Lett., "Lewis Acid-Mediated Electrophilic Thiolative Difunctionalization of Enimides: Rapid Access to β-Amino Sulfides" has been published recently (Yuanyuan Zhang, Jiaping Wu, Wangzhen Qiu, Lihao Liao*, Bo Wang, and Xiaodan Zhao* Org. Lett., 2023, 25, 5173-5178).
An efficient and practical route for the synthesis of β-amino sulfides by Lewis acid-mediated electrophilic thiolative difunctionalization of enimides is disclosed. A series of free phenols, electron-rich arene, alcohol, azide, and hydride, are successfully incorporated into the substrates in high regio- and stereoselectivities under mild conditions. The obtained products possess multiple functional groups and can be easily transformed to other valuable molecules.
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