Progress in the Construction of Spirocyclohexadienone Derivatives via Alkyne-involving Dearomatization
Congratulations! The publication of our group in Chin. J. Org. Chem., "Progress in the Construction of Spirocyclohexadienone Derivatives via Alkyne-involving Dearomatization" has been published recently (Peng Liu, Fuming Zhong, Lihao Liao, Weiqiang Tan*, and Xiaodan Zhao* Chin. J. Org. Chem., 2023, 43, 4019-4035).
Spirocyclohexadienones are not only widely present in bioactive molecules, but also act as key synthetic intermediates for the synthesis of natural products. Owing to the great importance of these compounds, their efficient synthesis has drawn considerable attention from synthetic chemists. In particular, there are many reports about the synthesis of spirocyclohexadienone derivatives via alkyne-involving dearomatization in the past few years. The success of these reactions benefits from the reaction mode: the activation of alkyne π bond by radicals, electrophiles, or metal catalysts under the conditions of photocatalysis, electrocatalysis, or chemical oxidation, and then the subsequent dearomatization process. This review systematically summarizes the advances in electron-deficient, -ordinary, and -rich alkynes-participated dearomatization of phenolic derivatives to realize the efficient construction of spirocyclohexadienone derivatives in recent five years. During the discussion, the used triggering ways are subdivided. At last, the prospects of this field are discussed.
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