Intermolecular Hydrazinative Halogenation of Alkenes with Potassium Halides as Nucleophilic Halogen Sources: Modular Entry to Phenelzine Derivatives
Congratulations! The publication of our group in Org. Lett., "Intermolecular Hydrazinative Halogenation of Alkenes with Potassium Halides as Nucleophilic Halogen Sources: Modular Entry to Phenelzine Derivatives" has been published recently (Nan Huang, Lihao Liao, and Xiaodan Zhao* Org. Lett., 2023, 25, 6587-6592).
An approach for the efficient synthesis of halogenated hydrazines via acid-mediated electrophilic hydrazinative halogenation of alkenes is disclosed. This transformation proceeds with readily available diethyl azodicarboxylate as a hydrazine source and low-cost potassium halides as nucleophilic halogen sources. A series of iodinated, brominated, and chlorinated hydrazines are facilely produced with a wide range of functional groups. The obtained products are good platform molecules. They can be conveniently converted into a variety of valuable phenelzine analogues which are appealing for development of novel drugs treating depression.
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